Use of promethazine injection is not recommended in children younger than 2 years of age because of the increased risk of respiratory depression. J Drug Educ. See also Warning section. Promethazine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. Promethazine (Phenergan) Dosage: One time dose: 12.5- 50 mg Onset of action: 2-5 minutes Peak effect: Unknown Duration of effect: More than 120 minutes Reversal Agent: None How useful was this post? It is best to inject this medication deep into a muscle. Plasma concentrations of promethazine required for sedative effects are unknown. PHENERGAN™ (promethazine hydrochloride) Suppositories, USPDESCRIPTION. Symptoms of Meniere's disease often fluctuate and include ringing, ear fullness, hearing loss, and poor equilibrium. phenergan onset My pulsatile tinnitus cleared up around August 2015 after 10 months. Each rectal suppository contains 12.5 mg or 25 mg promethazine HCl with ascorbyl palmitate, colloidal silicon dioxide, white wax, hard fat, and glyceryl monostearate. Rapid by IV (Phenergan) Duration. Onset: 20 minutes. They occur in 0.5% to 1% of patients given metoclopramide or prochlorperazine. This contraindication includes patients who have experienced agranulocytosis, bone marrow depression, blood dyscrasias, jaundice or other idiosyncratic reactions. Promethazine HCl is a racemic compound; the empirical formula is C 17 H. Onset of action occurs within 15-60 minutes after oral or rectal administration and within 20 minutes after intramuscular administration. Then I had onset of 'ordinary' T. Before Using. Read all of this leaflet carefully before you start taking this medicine because it contains important information for you sickness properties. Several area hospitals only allow it to be given by IVPB. My facility still pushes, most nurses dilute down first. Note recommended in prehospital setting since it can cause hallucinations, seizures, and death in children. Carefully follow your doctor's instructions when giving this medicine to a child of any age. Drug information provided by: IBM Micromedex. Promethazine may be used as adjunctive therapy in the management of nausea and vomiting of pregnancy when the preferred agents do not provide initial symptom improvement or when symptoms persist despite other. Although several theories have been proposed, the exact cause remains. Those affected may fidget, rock back and forth, or pace, while some may just have an uneasy feeling in their body. Promethazine is administered orally, rectally, intramuscularly, and intravenously. On site of application and thickness of skin. It also may interfere with blood grouping in the ABO system Monitor patient for onset of extrapyramidal side effects (akathisia—restless- ness; dystonia— musclespasmsandtwistingmotions; pseudoparkinsonism— mask-likeface,rigidity,tremors,drooling,shufﬂinggait,dysphagia).Notifyhealth. Promethazine can cause significant alterations of flare response in intradermal allergen tests if performed within 4 d of patient's receiving promethazine. Avoid use of promethazine in children with liver disease (including possible Reye's syndrome). Peak Action: 3.5 hours. I can no longer sleep naturally as the sounds are so loud I know how nasty Phenergan can be. Other neurological effects associated with promethazine poisoning:- Extensor plantar reflexes (Leak & Carroll, 1967) Abstract.